zelapar (selegiline HCl) Orally Disintegrating Tablets
About Zelapar
For Healthcare Professionals

Is Zelapar Right for You?

Zelapar® (selegiline HCl) is prescribed for PD patients as an addition to treatment with levodopa/carbidopa when they are having a reduced response to this therapy. Patients may notice, for example, that symptoms return before it’s time for their next dose. When once-daily Zelapar is added to levodopa/carbidopa medications, patients experience more active hours.

Zelapar is a novel form of selegiline because it dissolves in the mouth within seconds. This means that more active drug is delivered to the brain.

What difference will I notice if I take Zelapar?

Within one week patients should notice more active hours per day.

Are there any reasons not to take Zelapar?

Zelapar is not recommended:

  • If you are taking mereperidine or other opiods
  • If you are taking tricyclic antidepressants or SSRIs.
  • At doses exceeding 2.5 mg/day
  • If you are hypersensitive to selegiline or any of the inactive ingredients in Zelapar.

Rare cases of hypertensive reactions have been reported when patients have taken the recommended daily dose of conventional (tablets you have to swallow) selegiline and have eaten foods containing tyramine.

In general, at least 14 days should pass between treatment with a tricyclic antidepressant and treatment with Zelapar, and five weeks between treatment with Prozac® (fluoxetine) and treatment with Zelapar.

Remember that only your doctor can say for sure whether Zelapar is the right solution. Use the Doctor Visit checklist to start the dialogue.

 


Important Safety Information

Zelapar® is a special once-daily formulation of the drug selegiline that adds more active hours for patients with Parkinson’s disease (PD). Doctors may recommend adding Zelapar to levodopa/carbidopa treatment when patients are experiencing a reduced response to this therapy.

Do not take Zelapar if you are allergic to selegiline or any of the other ingredients in Zelapar. Zelapar should not be taken with certain medications. Discuss any medicine you are taking with your doctor. Zelapar should not be taken with meperedine (DEMEROL®) or other opiods. Rare cases of high blood pressure have been associated with taking conventional forms of selegiline with foods containing tyramine. Zelapar may cause you to have low blood pressure when you stand (this is more common in older patients than in younger ones). If you are pregnant, you must speak to your doctor about whether to take Zelapar. (Zelapar should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.) Do not take more than 2 tablets (2.5 mg) a day.

Zelapar was very well tolerated in clinical trials. The most commonly reported side effects were dizziness, nausea, pain, headache, trouble sleeping, runny nose, involuntary movements, back pain, skin disorders, mouth inflammation, and upper stomach pain. In addition, 5.2% of patients discontinued Zelapar therapy due to side effects (vs. 1% with placebo).

You may need your levodopa dose reduced after starting Zelapar therapy. Be sure to speak with your doctor if you experience any side effects.

Please see accompanying complete prescribing information.

Demerol® is a registered trademark of the Sanofi-Aventis Group. Prozac® is a registered trademark of Eli Lilly and Company.
Valeant Pharmaceuticals