zelapar (selegiline HCl) Orally Disintegrating Tablets
Understanding Parkinson’s Disease
For Healthcare Professionals

What is Parkinson’s Disease?

Parkinson’s disease is a disorder of the brain that affects body movement and emotions.

Named after Dr. James Parkinson, a London physician who first described the disease in 1817, Parkinson’s disease (PD) is a chronic, progressive disorder of the central nervous system. Once you get PD, it does not go away and the symptoms get worse over time. In general, tremor is followed by stiffness, slowness of movement (bradykinesia), and in the later stages, lack of balance. Emotional symptoms such as depression and anxiety are also characteristic of Parkinson’s disease.

PD patients have fewer dopamine-producing neurons.

Although the exact cause of PD is unknown, many of the symptoms occur when certain brain cells, called neurons, die or become damaged. Neurons produce a chemical substance called dopamine that is important in the control of movement. Over time, the dopamine level in the brain decreases and a chemical imbalance is caused that makes movement more difficult and less fluid. By the time characteristics of Parkinson’s disease like tremor and stiffness are visible, the normal level of dopamine has been greatly reduced.

Diagnosis.
Detecting PD in its early stages can be difficult, but most skilled practitioners can usually diagnose PD accurately.

If you think you might have Parkinson’s disease, or if your doctor suspects that you may, he will perform an assessment to detect Parkinson’s disease that consists of

• Taking your medical history

• Questions about things you do at home on a regular basis such as dressing, showering, bathing, walking, and eating

• A special exam by a neurologist

More sophisticated tests are available if a diagnosis is uncertain, but these are generally not used due to their cost and the overall strength of the standard exam.

If you receive a positive diagnosis.
At first, patients will probably have a lot of questions. Is this certain? Is it a good idea to get another opinion? Is medication right, or another form of therapy? What does the future look like?

Doctors will be able to answer most of these questions. It is important that patients and their doctors decide on the best treatment as soon as possible. The checklists on this site will help patients talk to their doctors about important things like medication, lifestyle changes, feelings or other concerns.

Often, doctors choose to treat Parkinson’s disease with levodopa/carbidopa, the mainstay of drug therapy for PD. In addition to levodopa/carbidopa treatment, doctors often prescribe other medications like Zelapar® (selegiline HCl).

» About Zelapar
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Important Safety Information

Zelapar® is a special formulation of the drug selegiline that adds more active hours for patients with Parkinson’s disease (PD). Doctors may recommend adding Zelapar to levodopa/carbidopa treatment when patients are experiencing a reduced response to this therapy.

Do not take Zelapar if you are allergic to selegiline or any of the other ingredients in Zelapar. Zelapar should not be taken with certain medications. Discuss any medicine you are taking with your doctor. Zelapar should not be taken with meperedine (DEMEROL®) or other opiods. Rare cases of high blood pressure have been associated with taking conventional forms of selegiline with foods containing tyramine. Zelapar may cause you to have low blood pressure when you stand (this is more common in older patients than in younger ones). If you are pregnant, you must speak to your doctor about whether to take Zelapar. (Zelapar should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.) Do not take more than 2 tablets (2.5 mg) a day.

Zelapar was very well tolerated in clinical trials. The most commonly reported side effects were dizziness, nausea, pain, headache, trouble sleeping, runny nose, involuntary movements, back pain, skin disorders, mouth inflammation, and upper stomach pain. In addition, 5.2% of patients discontinued Zelapar therapy due to side effects (vs. 1% with placebo).

You may need your levodopa dose reduced after starting Zelapar therapy. Be sure to speak with your doctor if you experience any side effects.

Please see accompanying complete prescribing information.

Demerol® is a registered trademark of the Sanofi-Aventis Group. Prozac® is a registered trademark of Eli Lilly and Company.
Valeant Pharmaceuticals